After studying at the Athens School of Fine Arts, he expanded his artistic horizons in Paris and Rome, where he developed his distinctive style that bridges traditional and modern art. Tsoclis is renowned for his innovative use of materials and his exploration of the interplay between painting, sculpture, and installation, often incorporating elements of light, space, and movement to create immersive experiences.

A defining moment in his career came in 1986 when he represented Greece at the Venice Biennale with his celebrated piece Seascape, a work that blurred the boundaries between art and reality. His creations often reflect themes of nature, mythology, and existential questions, inviting viewers to engage deeply with the artistic narrative.

Tsoklis's legacy extends beyond his art; he is the founder of the Costas Tsoclis Museum on Tinos Island, a space dedicated to showcasing his works and fostering cultural and educational initiatives. His monumental installations, such as Saint George Slaying the Dragon, further cement his reputation as an artist who pushes the limits of artistic expression. Now in his nineties, Tsoclis continues to inspire, leaving an indelible mark on the global art scene.